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Claudin-sixteen and you will claudin-19 was hemichannels you to definitely means an excellent paracellular pore permeable in order to calcium from the TAL

Claudin-sixteen and you will claudin-19 was hemichannels you to definitely means an excellent paracellular pore permeable in order to calcium from the TAL

Paracellular calcium supplements transportation in the TAL is facilitated by claudins, including the cation-selective pore-forming claudins ten and you may 16, and anion-clogging claudin-19 (76). It has been shown for the vitro (75, 78) and also in vivo (77, 79).

Claudin-sixteen are the initial claudin to get clinicians’ attention due to their part during the calcium supplements homeostasis (Table 1).